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Endurance Bundle

Endurance Bundle

$ 129.95 $ 166.75
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A convenient 2-month supply of pharmaceutical grade MultiNutrients w/o Copper and Iron, Ultra Pure Omega Mono 1300 EC, Bio-Curcumin-95, and CoQ10-100The Endurance Bundle is a uniquely balanced, research driven, convenient and time-tested antioxidant combination to energize, repair and protect you. The Endurance Bundle is a nutrient system that strategically supports today’s busy lifestyle. With a foundation of pharmaceutical grade vitamins and minerals, carefully selected antioxidants work simultaneously to repair and protect the foundation of cellular energy production throughout the body. So, whether you’re an elite endurance athlete or running in the marathon of life, this system allows stress to be just another state of vitality.

Bundle contains:

  • MultiNutrients w/o Copper and Iron - 1 bottle x120 capsules
  • Ultra Pure Omega Mono 1300 EC - 1 bottle x 60 capsules
  • Bio-Curcumin-95 - 1 bottle x 60 capsules
  • CoQ10-1 - 1 bottle x 60 capsules

 

Supportive Science

MultiNutrients w/o Copper & Iron

Good nutrition is a basis for wellness, and good nutrition usually translates into a stronger immune system and better health. An important aspect of good nutrition is micronutrition (vitamins and minerals). Micronutrients participate in converting food to energy; building and repairing tissues and DNA; manufacturing neurotransmitters, hormones, and other modulators in the body; breaking down and detoxifying xenobiotics and medications; and maintaining growth, reproduction, and health. According to research by the USDA and other organizations, the American diet is lacking micronutrients. In fact, nine out of 10 Americans are missing key micronutrients. Mass food production, storage techniques, poor food choices, and nutrient-depleting preparation methods may contribute to inadequacies. The bottom line is that children and adults are not consuming enough nutrient-rich foods to meet all their most basic vitamin and mineral needs. What’s more, some scientists feel that the recommended intakes (e.g., %DV, DRIs, EARs, RDAs) may not meet the requirements of all individuals, especially the chronically ill.*

There are numerous reasons to select MultiNutrients without Copper & Iron:

Balanced Profile Vitamins and minerals work synergistically and cooperatively when present in proper amounts. However, imbalances between micronutrients can disrupt this synergistic relationship, possibly leading to instances of competitive intestinal absorption or displacement at the metabolic/cellular level, which can produce relative excesses and insufficiencies. For this reason, MultiNutrients without Copper & Iron features a balanced nutrient profile that includes calcium and magnesium, zinc and copper, vitamins C and E, bioactive folate, vitamin B12, B vitamin complex, beta-carotene, and trace elements.*

Bioavailability The micronutrients are provided in bioavailable forms so that they can be better absorbed and utilized. MultiNutrients without Copper & Iron contains a full complement of Albion® patented mineral chelates and complexes. Albion is a recognized world leader in mineral amino acid chelate nutrition and manufactures highly bioavailable nutritional mineral forms that are validated by third-party research and clinical studies. Not only do these formulas contain natural vitamin E, which has been proven to be up to 100% more bioavailable than synthetic dl-alpha-tocopherol, but it is also provides mixed tocopherols to more closely approximate how one might consume vitamin E in healthful foods. Folate is provided as 5-methyltetrahydrofolate (5-MTHF)—the most bioactive form of folate. MultiNutrients without Copper & Iron features 5-MTHF as Quatrefolic®, which is proven to have greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF. Vitamin B12 is provided as MecobalActive™. This patented form of methylcobalamin has very high purity; no harmful solvents are used in its production. Vitamins B2 and B6 are also provided in activated forms.*

Energy Production MultiNutrients without Copper & Iron provides generous levels of B vitamins, which serve as prime coenzymes in glycolysis and oxidative phosphorylation and as cofactors in amino acid and lipid metabolism. The balanced presence of B vitamins is essential to their cooperative functioning and excellent for those with stressful lifestyles.*

Antioxidant Protection Vitamins E and C, selenium, zinc, beta carotene, and trace elements provide broad-spectrum antioxidant activity. Their combined presence supports their ability to regenerate each other and maintain consistent levels of antioxidant activity both intra- and extracellularly.*

Detoxification Support Xenobiotics, including environmental pollutants and medications, must undergo biotransformation into molecules that can be easily excreted from the body. There are significant levels of bioavailable riboflavin, niacin, folate, and B12 present in these formulas to support phase I detoxification. Beta carotene, vitamin C, tocopherols, selenium, copper, zinc, and manganese are present to protect tissues from reactive intermediates formed between phase I and phase II detoxification.*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Ultra Pure Omega Mono 1300 EC

MaxSimil® Patented Lipid Absorption Enhancement Technology (PLATform)
The MaxSimil PLATform is a novel monoglyceride delivery system that enhances absorption of lipid-based and lipid-soluble nutraceutical and food ingredients. This technology has been applied to Physician Nutrients®’s Ultra Pure Omega Mono 1300 EC in order to create a unique vehicle by which to deliver EPA and DHA. Due to the fact that monoglyceride oils are intrinsically emulsifiers and are by nature, in a readily absorbable form and they can bypass the body’s normal fat digestion process. These qualities make Ultra Pure Omega Mono 1300 EC an excellent vehicle for delivering omega-3 fatty acids, especially to individuals with digestive, pancreatic, or gall bladder challenges. Studies show that MaxSimil fish oils (FO) have three times (300%) greater absorption of EPA and DHA compared to other leading fish oils.*

Figure 1

Quality
Ultra Pure Omega Mono 1300 EC is made using proprietary MaxSimil compositions containing monoglyceride FO with no additional ingredients, carriers, or excipients. Each fish-gelatin softgel is enteric-coated, and every batch of fish oil is certified to ensure the world’s highest standards for purity, potency, and freshness. The fish oil is non-GMO, certified sustainable from Scandinavia, and antibiotic-free. Additionally, it is eco-friendly because the greater absorption of EPA and DHA ultimately means that fewer grams of fish oil need to be harvested for the same benefit.*

In Vitro and In Vivo Animal Studies
The ability of MaxSimil-enhanced EPA and DHA to positively influence growth inhibition and apoptosis in colorectal, breast, lung, and prostate diseased cell lines was first demonstrated in a series of in vitro studies. Researchers subsequently set out to demonstrate efficacy in animal models after oral administration. In three separate animal models, MaxSimil EPA and DHA forms showed superior activity on diseased cell-line growth inhibition and cytokine production when compared to control, corn oil, krill oil, or the parent forms ethyl ester (EE) EPA and ethyl ester (EE) DHA. These in vivo animal studies proved that orally supplemented MaxSimil EPA and DHA were well-absorbed and bioactive. Researchers postulated that the observed superior effects of MaxSimil EPA and DHA forms were the result of enhanced absorption, and they set out to prove this hypothesis.*

Preclinical Bioavailability Studies
The in vivo pharmacokinetic studies in rodents involved a comparison between MaxSimil DHA FO and its parent EE DHA FO and an analysis of blood concentrations of DHA over time. The doses used were equivalent to human doses of 3 g/day and 30 g/day; the latter was included primarily to investigate toxicity at high doses. Researchers found that MaxSimil DHA FO had a three times (3x) higher peak concentration (6%versus 2%, Figure 2), a 3x higher saturation potential at the high dose (10% versus 3%), and a 3x higher absorption rate (at a 3 g/day equivalent human dose) than its parent DHA FO. No toxicity was observed at either dose level. This research demonstrated superior bioavailability and presumably better exposure of cells to DHA.*

Figure 2

Clinical Bioavailability Study
A phase 1, double-blind, randomized, crossover, pharmacokinetic study was performed in 20 healthy adults aged between 19 and 71 years who were administered 6 g (containing 1800 mg EPA and 1200 mg DHA) per day of EE FO or MaxSimil FO. Parameters studied were plasma EPA and DHA concentration (as percent of total fatty acids), Cmax, and AUC. Compared to EE EPA+DHA, the results indicated that at peak concentration, MaxSimil EPA and DHA forms were 3x higher, they reached maximum concentration faster, and maintained their plasma levels longer. The finding in the animal study was validated: the MaxSimil FO instantaneous absorption was 3x greater than the EE form. Likewise, the AUC over 24 hours was also more than 3x higher (P<.0001) for MaxSimil EPA and DHA (MaxSimil FO).*

Not only did this study confirm the bioavailability findings in the animal study, but it also demonstrated that after 24 hours, the MaxSimil FO maintained 2-3x higher blood levels of EPA and DHA than the EE FO. This means that, given a daily dose, circulating EPA and DHA levels can be expected to ramp up over time and remain high with steadily increasing exposure of cells to EPA, DHA, and their metabolites. Based on the results of the bioavailability studies, an individual would get more EPA and DHA from MaxSimil FO than from EE FO gram for gram. Furthermore, as shown in the animal studies, one could anticipate enhanced effects. It is noteworthy that all 20 adults who completed the study saw their omega-3 absorption enhanced when taking the MaxSimil enhanced FO.*

Figure 3

Expanding Research
In vitro and animal studies have demonstrated the positive effects of MaxSimil FO on airway immune response (e.g., IgE, leukocytes); the expression of COX-2, NF-kB, cytokines (e.g., IL-6, IL-8), MUC5AC, and mucin; and Ca(2+) hypersensitivity in lung tissues. In other research, rats subjected to eight weeks of a high-fat, high-carbohydrate diet were either not supplemented or provided 3 g/day of MaxSimil DHA. Compared to the data from the non-supplemented group, the data from the MaxSimil DHA supplemented group clearly showed a positive impact on cardiovascular health parameters. Measures included blood pressure, heart rate, serum lipid levels, cytokine production, aortic wall thickness, and a DHA:AA ratio in aortic tissue, which correlated with the production of resolvin D2 and D3 metabolites.*

A Note About Resolvins and Other EPA and DHA Metabolites
Specialized proresolving (cell signaling molecules formed in cells as a result of PUFA metabolism that help resolve cellular inflammation) lipid mediators, such as resolvins, protectins, and maresins, are EPA and DHA metabolites naturally produced in vivo through enzymatic conversion of EPA and DHA. These mediators aid the body’s “clean-up” response to the arachidonic acid cascade. Rather than supplying a single molecule or metabolite, which would mirror the pharmaceutical model, Ultra Pure Omega Mono 1300 EC provides all the benefits of EPA and DHA as well as the expected and desirable benefits of their metabolites.*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Bio-Curcumin-95

Curcumin, the principal curcuminoid in turmeric, has been the subject of vast research in recent years. The pleiotropic nature of curcumin’s biological effects make it an interesting compound to researchers who study common chronic health concerns, such as those associated with joints, the cardiovascular system, glucose metabolism, brain function, mood, and cell-cycle regulation.*

The mechanisms underlying curcumin’s effects are diverse and have not been fully elucidated, but it is known that curcumin has powerful antioxidant activity and that it has multiple molecular targets, including transcription factors, cell cycle proteins, cytokines, chemokines, enzymes (e.g., COX-2), receptors, and adhesion molecules. These effects make curcumin applicable to a wide array of clinical presentations.*

Patented Formulation: BCM-95®

While the beneficial effects of curcumin are hardly arguable, an area of intense research is how to make curcumin more bioavailable. Poor absorption in the gastrointestinal (GI) tract, rapid metabolism, and rapid systemic elimination are characteristics of commercially available curcumin preparations. While investigating a way to overcome these challenges, scientists discovered they could take advantage of the synergism between the curcuminoids and the sesquiterpenoids (essential oils) naturally present in turmeric. This discovery resulted in the development of BCM-95—a 100% natural whole turmeric extract composed of 86% curcuminoids (curcumin, demethoxycurcuminoid, and bisdemethoxycurcuminoid) and 7%-9% essential oils.*

Essential oils are a natural component of the turmeric rhizome. Not only do they enhance absorption of curcuminoids, but they also impart health benefits. The essential oils found in BCM-95 are extracted using double steam distillation. Essential oils comprise 7% to 9% of turmeric, with 50% of that being ar-turmerone, alpha-turmerone, and beta-turmerone. Some of the other essential oils present in BCM-95 include ar-curcumene, alpha-curcumene, zingiberene, beta-sesquiphellandrene, beta-atlantone, and germacrone.*

The Bioavailability of BCM-95

Animal and human studies have demonstrated the superior bioavailability of the BCM-95 curcumin composition. In a pilot crossover study, Antony et al compared the bioavailability of three forms of curcumin: BCM-95, normal curcumin, and a non-controlled release curcumin-piperine-lecithin formula. The data demonstrated that the absorption of curcumin from BCM-95 was fast, peaked at 4.5 hours with a gradual decline, and that curcumin was still detectable in the blood at eight hours. The other formulas showed slower curcumin absorption with an earlier peak and rapid disappearance from the blood after 4.5 hours. The relative bioavailability of BCM-95 was approximately 6.93-fold higher than normal curcumin and 6.3-fold higher than the non-controlled release curcumin-lecithin-piperine formula. According to the researchers, the results of this study indicate that the BCM-95 curcumin is “absorbed early and retained longer” compared to other forms.*

Unlike other bioavailability-enhanced curcumin formulas, BCM-95 does not contain any non-turmeric compounds; no phospholipids, excipients, additives, carriers, nanotechnology, or bioenhancers are used.

BCM-95 Studies

To date, BCM-95 is backed by more than 21 published studies and over 12 years of research conducted around the world. Unlike many commercially available curcumin formulas, the bioavailability, safety, and efficacy of BCM-95 curcumin has been demonstrated in numerous preclinical and human studies. The following areas illustrate the massive body of research behind BCM-95 in relation to common health concerns: colon health, mood and stress, cognitive health, joint health, urinary health, cytokine modulation, prostate health, breast health, and cardiovascular health.*

As an example of the findings, in an eight-week randomized, double-blind, placebo-controlled trial (n=56), ingestion of 500 mg BCM-95 twice daily resulted in significant improvements in mood-related parameters during weeks four to eight. These findings are supported by related research into curcumin’s effect on mood. In another study, the effects of BCM-95 on joints were evaluated. The BCM-95 group (500 mg for eight weeks) showed the highest percent of improvement in scoring related to joint health and comfort.*

In addition to the aforementioned published studies, eight human clinical trials using BCM-95 for periods of 21 days to one year are currently underway at prestigious institutions, including several at Baylor University Medical Center at Dallas.

Safety and Dosing

Turmeric has been safely consumed for thousands of years, and its medicinal compound curcumin has an outstanding safety profile. Phase I clinical trials using up to 8 g/d for four months did not result in discernable toxicities. Mild gastrointestinal distress can sometimes accompany curcumin supplementation, but this may be minimized by consuming the supplement with food. Current doses in clinical trials using BCM-95 range from 500 mg/d to 1000 mg/d.*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

CoQ10-100

Coenzyme Q10 (CoQ10) is a fat-soluble substance that plays a major role in energy production and antioxidant protection in the body. It is found in the body primarily in its interchangeable ubiquinone and ubiquinol forms. In general, CoQ10 supports mitochondrial energy production, antioxidant activity, cell membrane stabilization, gene expression and apoptosis, and neurological and cardiovascular health. Levels of CoQ10 in the body can be affected by a number of factors. Dietary contribution of CoQ10 is minimal and serum levels tend to decline with age or can be reduced due to drug-induced nutrient depletion.*

Synthesis of CoQ10 in the body is regulated by the enzyme HMG-CoA reductase. A variety of factors can inhibit HMG-CoA reductase and hinder CoQ10 production and availability, resulting in a potential increase in oxidative stress and a decrease in energy generation. In the event of reduced production, or drug-induced nutrient depletion, physicians recommend supplementation with CoQ10 to help maintain normal levels in the body. Supplementation with CoQ10 has been found to promote favorable outcomes for a targeted group of patients and to improve quality of life, energy levels, neurological health maintenance, exercise tolerance, and muscle comfort for a wide range of individuals. A research study utilizing functional intracellular assay (FIA) suggested that CoQ10 may be a potential peripheral biomarker of antioxidant status in neurological health maintenance.*

Cardiovascular health is particularly dependent upon CoQ10 because of the heart muscle’s exceedingly high energy demand. The value of CoQ10 supplementation on cardiovascular health has been confirmed by ongoing human research studies. A randomized, double-blind, placebo-controlled study utilizing the same bioidentical, naturally yeast-fermented CoQ10 found in CoQ10-100 was conducted in a select group of 49 patients. Researchers observed that supplementation with 100 mg/d of CoQ10 successfully restored plasma levels and significantly increased total CoQ10 levels by 127%.*

Results from the highly anticipated Q-SYMBIO research study were reported in May 2013. Prior to the Q-SYMBIO study, researchers had observed that myocardial CoQ10 levels were inversely related to heart health and function. The Q-SYMBIO results, in fact, supported this association. In the randomized, double-blind, placebo controlled Q-SYMBIO study, 420 patients were assigned to parallel groups to receive either the CoQ10 found in CoQ10-100 (100 mg three times per day) or placebo. Within three months, researchers observed a reduction in N-terminal pro-brain natriuretic peptide (NT-proBNP), an important marker of heart health, in the CoQ10 supplemented patients. After two years, patients who were supplemented with CoQ10 had significant cardiovascular improvement overall compared to placebo.*

CoQ10-100 contains a unique, crystal-free, highly bioavailable form of ubiquinone and represent a new generation of CoQ10 supplementation. This soy-free formulation contains five lipids that help dissolve CoQ10 crystals into single molecules. This process helps stabilize the formula to prevent re-crystallization and facilitates passive diffusion to enhance absorption. Earlier generation supplements were poorly absorbed (0.6-1.0%), pure crystalline (powdered) forms of CoQ10, which served as the industry standard from the mid-1970s to the mid-1990s. A variety of forms and delivery systems offered somewhat improved absorption (2.3-5%) after 1995; however, these forms were unstable and crystallized and therefore difficult for the body to absorb. The five-lipid carrier, crystal-free CoQ10 in Physician Nutrients’s CoQ10-100 represents innovation and improvement in CoQ10 delivery and bioavailability.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

MultiNutrients w/o Copper & Iron

MultiNutrients without Copper & Iron Supplement Facts

Ultra Pure Omega Mono 1300 EC

Ultra Pure Omega Mono 1300 EC Supplement Facts

Bio-Curcumin-95

Bio-Curcumin-95 Supplement Facts

CoQ10-100

CoQ10-100 Supplement Facts


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