By Alexandria Bachert, Staff Writer, MedPage Today, April 26, 2017
Drinking a high-volume energy drink was linked to more heart and blood pressure changes compared with a control drink containing the same amount of caffeine, according to a small crossover study of military personnel.
Those in the energy drink arm had a significantly higher change in corrected QT interval, a measure of cardiac repolarization, compared with those in the caffeine arm at 2 hours after baseline (0.44 ms versus 10.4 ms, P=0.02), reported Emily A. Fletcher, PharmD, of David Grant U.S.A.F. Medical Center at Travis Air Force Base Fairfield, Calif., and colleagues.
John P. Morrow, MD, of Columbia University Medical Center in New York City, told MedPage Today that the study confirms previous findings that caffeine is probably safe in moderate doses.
"The bad news is that energy drinks may have concerning short-term effects on the cardiovascular system, although they are unlikely to cause serious side effects in healthy young people," said Morrow, who was not involved in the study.
Fletcher's group recruited 18 participants (12 men) via email and flyers from 2013 to 2014 on a U.S. Air Force Base installation. All participants were randomized to receive 32 oz of a commercially available energy drink or a control drink, both which contained 320 mg of caffeine. After a 6-day washout period, participants switched drinks.
The researchers collected ECG, peripheral blood pressure, and central blood pressure measurements at baseline and at 1, 2, 4, 6, and 24 hours after drink consumption.
While both groups initially had similar increases in systolic blood pressure, a significant difference was evident after 6 hours in the energy arm but not the caffeine arm (4.72 mm Hg versus 0.83 mm Hg, P=0.01).
Additionally, the researchers reported a significant decrease in baseline-adjusted augmentation index after 6 hours in the energy drink arm compared with the caffeine arm ( 3.72 versus 1.50, P=0.02). No difference was seen with heart rate, diastolic blood pressure, central systolic blood pressure, and central diastolic blood pressure at any time point between the two groups (P>0.07).
The authors concluded that the findings "suggest that ingredients other than caffeine may have some blood pressure altering effects, but this needs further evaluation."
Study limitations included the absence of a true placebo and that the results only appeared to be significant relative to the caffeine group.
However, "that being said, the results are of interest and serve as hypothesis generating for larger, more adequately powered studies to assess for a true effect of energy drinks on cardiac repolarization (the QT interval) and peripheral blood pressure," wrote Eugenio in an email.
Morrow agreed, noting that different energy drinks with different herbal or chemical ingredients may have different effects on the cardiovascular system.
"We cannot assume class effects, and we cannot assume that herbal/natural preparations are always safe. More work is needed, and we should not extrapolate these results to middle-age healthy people, or elderly people with heart disease," he told MedPage Today.
From the American Heart Association:
The study was funded by the Clinical Investigations Facility at Travis Air Force Base.
Fletcher and co-authors disclosed no relevant relationships with industry.
Journal of the American Heart AssociationSource Reference: Fletcher E, et al "Randomized controlled trial of high-volume energy drink versus caffeine consumption on ECG and hemodynamic parameters" J Am Heart Assoc 2017; DOI:10.1161/JAHA.116.004448.