Magnesium, the fourth most abundant mineral in the human body, plays a role in over 300 metabolic processes. It participates in the development and maintenance of bones and teeth; the metabolism of carbohydrates, blood glucose, fats, and proteins; the formation of cells and tissues; and the maintenance of muscle function, including cardiac muscle. MagThreonate features Magtein™ (magnesium L-threonate), the only form of magnesium proven in animal studies to cross the blood-brain barrier. Boosting the brain’s magnesium level is vital to healthy cognition, which includes long- and short-term memory, learning, stress management, and sleep. MagThreonate also contains Albion®’s TRAACS® magnesium lysinate glycinate (mineral amino acid chelate) and Albion’s chelated dimagnesium malate—both formulated for enhanced absorption. Malic acid (from di-magnesium malate) supports energy production and lactic acid clearance via the Krebs cycle. Malic acid may also support antioxidant systems by enhancing glutathione and antioxidant enzymes.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Details

150 g (5.29 Ounces) 

Applications:

Supports Healthy Brain Magnesium Levels*

Supports Healthy Synapse Number and Function*

Supports Cognitive Health*

Supports Stress Management, Sleep Quality, and a Healthy Mood*

Helps Ensure an Optimal Magnesium Intake for Overall Health*

Directions:

Dissolve one level scoop in 4 oz water or adjust amount of water to desired sweetness. First week: one serving per day immediately before dinner or one hour before bedtime. Thereafter: one serving during the day, preferably mid-afternoon, and a second serving before bedtime; or use as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

Does Not Contain: Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Supportive Science

MagThreonate – Optimizes Magnesium Delivery to Body and Brain

Dietary intakes of magnesium are consistently below minimum recommended levels, and an insufficiency of magnesium is implicated in a wide range of health concerns, including those that affect the brain. Because many forms of magnesium have low bioavailability, selected magnesium compounds backed by research and studies were carefully selected to formulate MagThreonate. MagThreonate features a unique combination of highly absorbable, organic Albion minerals—di-magnesium malate and TRAACS® magnesium lysinate glycinate chelate—and MagteinTM. Magtein is a groundbreaking organic magnesium compound that was developed by MIT (Massachusetts Institute of Technology) researchers to support “brain power.”*

Magtein – Patented Magnesium L-Threonate

Magtein is the result of 10 years of research at MIT. This novel form of magnesium is changing the way we support brain health. Unlike other brain products on the market that work via brain stimulation (often overstimulation), Magtein works via a completely different mechanism. When brain magnesium levels are not optimal, synapse function deteriorates. By delivering magnesium into synapses, Magtein helps brain cells stay healthy, without being overactivated; consequently, brain cells respond to signals with clarity and robustness.*

Magtein Raises Brain Magnesium Levels

Studies show that Magtein crosses the blood-brain barrier and raises the brain’s magnesium levels, which result in increased magnesium deposits in neural synapses, increased neural synaptic density, and improved brain function. One animal study showed that when the bioavailability of several magnesium compounds was compared to controls, only Magtein significantly enhanced magnesium bioavailability and produced a significant increase (7% to 15%) in rat cerebrospinal fluid. These small but significant increases in brain magnesium levels produced profound effects on neurological function.*

Magtein Supports Healthy Synaptic Number and Function

Maintaining extracellular magnesium in the brain helps preserve synaptic density and keeps the synapses working properly. By increasing magnesium concentration in the extracellular fluid, researchers observed permanent enhancement of synaptic plasticity in networks of cultured hippocampal neurons. Delving deeper into the mechanisms involved, later animal research showed that magnesium increased receptor signaling; specifically, the signaling of the NR2B-containing N-methyl-D-aspartate (NMDA) receptor. NMDA receptors are rich in the hippocampus and play a pivotal role in memory processes. Data from these studies suggest that increasing brain magnesium with Magtein “enhances both short-term synaptic facilitation and long-term potentiation and thereby supports synaptic plasticity and learning and memory functions in rats.”*

Magtein Supports Cognitive Health

The benefits of Magtein were observed in several pre-clinical animal studies that used assessments, such as the NORT (novel object recognition test), T-maze, Morris water maze, conditioned fear memory, and conditioned taste aversion. In these studies, researchers demonstrated that when brain magnesium levels were increased, significant benefits were detected in multiple aspects of learning and memory in young and aged rodents. For instance, the work of Slutsky et al revealed an 18% increase in short-term memory and a 100% increase in long-term memory with oral administration of Magtein.*

One study examined the effects of Magtein in test mice (genetically altered mice that model age-related cognitive changes). Li et al found that the test mice not given Magtein exhibited “unequivocal learning deficits,” while the test mice given Magtein performed similarly to normal mice. In short, Magtein helped preserve normal brain function. When magnesium levels in the brain tissue were quantified, the relationship became even clearer: According to researchers, brain magnesium levels positively correlated with cognitive function; that is, the lower a mouse’s brain magnesium level, the poorer its memory function in the NORT task. Furthermore, histological analysis of brain tissue showed that Magtein administration preserved synapse density and NMDA receptor signaling and also had positive effects on the expression of certain proteins associated with changes in memory.*

A large-scale human clinical trial has recently been completed. The results, publication forthcoming, support the in vitro and animal findings that Magtein positively affects memory, cognition, and synapse density.*

Magnesium in Stress Management, Sleep Quality, and Mood

Magnesium is known to benefit the body in ways that counter stress, promote restful sleep, and support a healthy mood. In rats, magnesium administration attenuated neurologic changes brought on by chronic mild stress. Additionally, by increasing fear memory extinction, Magtein showed promise as a modulator of worry. In human studies, magnesium supplementation partially reversed sleep changes associated with aging and improved objective and subjective measures of sleep. Improving sleep quality and countering the effects of chronic stress positively impact mood— another area that is beneficially influenced by optimal magnesium status.*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.